Coming Off Weight Loss Injections in Midlife: How to Maintain Your Results Without Going Backwards

“I’m scared I’m going to put all the weight back on.”
If you’ve recently decided to stop weight loss injections like Mounjaro or Wegovy, you might be feeling this too.

Maybe the side effects became too much.
Maybe the cost felt unsustainable.
Or maybe you just knew it wasn’t something you wanted to be on forever.

Whatever your reason, stepping away from these medications can feel like standing at the edge of a cliff — unsure whether you’ll land on solid ground or tumble back to where you started. And if you’re in perimenopause or postmenopause, the fear can feel even bigger because your body already feels like it’s shifting under your feet.

I want you to know this: you are not doomed to regain all the weight.
But — and here’s the honest part — it does take a thoughtful, supported transition.

Why weight regain happens after stopping injections

Weight loss injections work by influencing appetite, blood sugar regulation and digestion. When you stop taking them, those effects stop too.
Your hunger cues may return more strongly, your cravings may feel louder and your body may start to defend the weight it’s just lost — especially if it senses a “famine” situation.

Layer on the hormonal changes of menopause (hello oestrogen drop, muscle loss, and shifting fat distribution), and it’s easy to see why this is a vulnerable time for weight regain.

But there’s good news: with the right tools, you can keep your hard-earned progress.

How I help women through this transition

As a Health & Nutrition Coach specialising in menopause, I work with women in this exact position. Our focus isn’t on going “back on a diet” or punishing the body — it’s about creating a new foundation for your health that supports your biology now.

Here’s how:

1. Stabilising blood sugar
We rebuild your nutrition to keep your energy steady, your appetite in check and those post-injection cravings from taking over. This often means pairing protein and fibre at every meal, eating enough (not less) and timing meals in a way that works with your daily rhythm.

2. Protecting muscle
Menopause already accelerates muscle loss and losing muscle means losing metabolic strength. We focus on strength training that’s hormone-aware — so you keep burning energy efficiently and stay strong for daily life.

3. Managing stress and sleep
Poor sleep and chronic stress can quickly trigger weight regain, especially in midlife. We work on simple, realistic routines that help your body feel safe enough to let go of the “emergency mode” it slips into after stopping medication.

4. Mindset & habits for the long game
Quick fixes aren’t the answer. Together, we build habits that feel natural and sustainable, so you’re not relying on willpower alone.

The real results

The women I’ve supported through this transition often tell me the same thing:
“I feel like I’ve got my life back — without the fear.”

They’re maintaining their weight, feeling stronger, and most importantly, they trust their body again.
They’re not chained to a medication, a number on the scale, or a rigid set of rules.

If this is you

If you’re coming off weight loss injections and want to keep the progress you’ve made — while feeling energised, confident, and in control — you don’t have to figure it out alone.

This is your opportunity to create a health plan that works with your hormones, not against them.

If you’d like personalised support, you can connect with me here:
📍 Learn more about 1:1 coaching at The Menopause Health Coach

Your body is capable of so much more than just “holding on” — it’s capable of thriving.

Research & Clinical Insights

1. Healthline – Weight Regain After Stopping Mounjaro
   Research indicates that patients who stopped taking Mounjaro regained about 14% of the weight they lost after one year.

2. Drugs.com – Maintaining Weight Loss After Mounjaro
   Structured behavioral support, meal spacing, and regular follow-ups with healthcare providers can help prevent weight regain after stopping Mounjaro.

3. JAMA Network – Discontinuation of GLP-1 Receptor Agonists
   Discontinuation of GLP-1 receptor agonists like Mounjaro can lead to weight regain, emphasizing the need for continued lifestyle modifications.

4. The Guardian – Weight Regain After Stopping Weight Loss Drugs
   Analysis shows that individuals often regain weight within a year after stopping weight loss medications, highlighting the importance of sustainable lifestyle changes.

5. PMC – Weight Gain Following Discontinuation of GLP-1 Receptor Agonists
   A comprehensive review indicates that discontinuation of GLP-1 receptor agonists leads to significant weight gain, underscoring the necessity of ongoing weight management strategies.

Expert Guidance & Lifestyle Strategies

1. The Times – 21 Rules to Keeping Weight Off
   Experts recommend increasing protein, fibre and healthy fats, maintaining high physical activity and adding resistance training to preserve muscle and metabolism.

2. SF Chronicle – The 'Single Most Important Behavior' for Women in Menopause
   Emphasises the importance of diet and strength training for managing weight during perimenopause and menopause.

3. Mayo Clinic – The Reality of Menopause Weight Gain
   Discusses how hormonal changes during menopause affect metabolism and provides tips for managing weight.

4. Menopause.org.au – Maintaining Your Weight and Health During and After Menopause
   Highlights the benefits of healthy lifestyle choices, including diet and physical activity, in maintaining weight and health during and after menopause.